Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrathecal interferon in multiple sclerosis.

L Jacobs, J O'Malley, A Freeman

    Archives of Neurology
    |October 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Recurrent Urethral Phyllodes Tumour Presenting With Urinary Retention: A Case Report and Literature Review.

    Case reports in urology·2026
    Same author

    A diagnosis of syphilis following a radical circumcision for suspected penile cancer.

    Annals of the Royal College of Surgeons of England·2024
    Same author

    A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium.

    Nature medicine·2023
    Same author

    A large dermoid cyst of the spermatic cord.

    Annals of the Royal College of Surgeons of England·2023
    Same author

    A survey in the West Midlands of the United Kingdom of current practice in managing hypotension in lower segment caesarean section under spinal anaesthesia.

    International journal of obstetric anesthesia·2023
    Same author

    Three-dimensional quantification of fibrosis and ossification after cochlear implantation via virtual re-sectioning: Potential implications for residual hearing.

    Hearing research·2022

    Intrathecal administration of human fibroblast interferon-beta (IFN-beta) in multiple sclerosis (MS) patients significantly reduced exacerbation rates. This treatment shows promise for altering MS disease course.

    Area of Science:

    • Neuroimmunology
    • Viral Immunology

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease with limited treatment options.
    • Understanding the immunopathogenesis of MS is crucial for developing effective therapies.

    Purpose of the Study:

    • To evaluate the feasibility and efficacy of intrathecal administration of human fibroblast interferon-beta (IFN-beta) in patients with MS.
    • To assess the impact of IFN-beta on disease exacerbation rates and clinical course.

    Main Methods:

    • Ten MS patients received serial lumbar puncture administration of IFN-beta.
    • A control group of ten MS patients did not receive IFN-beta.
    • Clinical courses were monitored and compared between groups over a mean follow-up period of 1.9 years for recipients and 1.6 years for controls.

    Related Experiment Videos

    Main Results:

    • IFN-beta recipients experienced significantly fewer exacerbations compared to their pre-study rates.
    • Control patients showed no significant change in exacerbation rates.
    • Five IFN-beta recipients showed clinical improvement, compared to two controls.

    Conclusions:

    • Intrathecal IFN-beta administration is feasible in MS patients.
    • This treatment approach warrants cautious optimism for altering the disease course.
    • Findings support viral or dysimmune etiology theories for MS.