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Related Experiment Videos

Rapid and slow rate of decrease in HbA1a + b and HbA1c during improved glycaemic control.

H Arnqvist, G Cederblad, G Hermansson

    Scandinavian Journal of Clinical and Laboratory Investigation
    |May 1, 1982
    PubMed
    Summary
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    Rapid improvements in blood glucose control lead to a biphasic decrease in glycosylated haemoglobins (HbA1a+b and HbA1c). The initial, faster decline may be influenced by labile HbA1, impacting long-term glycemic control assessments.

    Area of Science:

    • Endocrinology
    • Metabolic Disorders
    • Clinical Chemistry

    Background:

    • Glycosylated haemoglobins (HbA1a+b and HbA1c) are key indicators of long-term glycemic control in diabetic patients.
    • Rapid improvements in glycemic control can alter HbA1 levels, potentially affecting interpretation.

    Purpose of the Study:

    • To investigate the kinetics of glycosylated haemoglobin changes following rapid glycemic control improvement.
    • To determine if the decrease in HbA1a+b and HbA1c occurs in a single or multiple phases.

    Main Methods:

    • Column chromatography was used to measure HbA1a+b and HbA1c levels.
    • Nine diabetic patients with rapidly improved glycemic control were monitored for at least 3 weeks.

    Main Results:

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    • A biphasic decrease in both HbA1a+b and HbA1c was observed within the first few days of improved control.
    • The initial decrease in HbA1a+b and HbA1c was faster than the subsequent decline.
    • Individual patient data showed a correlation between the initial rate of decrease in glycosylated haemoglobins and blood glucose.

    Conclusions:

    • Glycosylated haemoglobins (HbA1a+b and HbA1c) exhibit a biphasic reduction pattern during rapid glycemic control improvement.
    • A labile HbA1 fraction likely contributes to the rapid initial decrease, potentially influencing HbA1's utility as a long-term glycemic control marker.