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Platelet consumption in cardiovascular disease.

A G Turpie, A C de Boer, E Genton

Seminars in Thrombosis and Hemostasis

|July 1, 1982

Summary

Platelet tests for thromboembolism show limited value. While some platelet activation is seen in large vessel or recurrent venous issues, tests lack sensitivity for common arterial diseases.

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Area of Science:

Hematology
Vascular Medicine
Thrombosis Research

Background:

Numerous tests exist to study platelet roles in arterial and venous thromboembolism.
Early platelet reactivity tests offered limited insight into platelet consumption in thromboembolic diseases.
Recent advancements include in vivo platelet release, survival, and turnover tests.

Purpose of the Study:

To evaluate the diagnostic and clinical utility of platelet function tests in thromboembolic disorders.
To determine if current platelet tests can reliably detect platelet activation and consumption in various vascular conditions.
To assess the sensitivity and specificity of platelet tests in managing patients with thromboembolic diseases.

Main Methods:

Review of studies utilizing various platelet function assays, including platelet survival time and in vivo platelet release.
Analysis of data correlating test results with different thromboembolic conditions, such as arteriosclerosis, venous thromboembolism, and prosthetic device complications.
Assessment of test sensitivity and specificity in detecting platelet activation.

Main Results:

Platelet tests have variable mechanisms and early studies were of limited value.
Recent tests show potential but data remain inconclusive for arteriosclerosis-associated thromboembolism.
Abnormalities are consistently found in acute/recurrent venous thromboembolism and with older prosthetic devices.

Conclusions:

Current platelet function tests lack sufficient sensitivity and specificity for widespread clinical application in thromboembolic disorders.
Platelet survival time may indicate platelet consumption in specific conditions like large vessel disease and recurrent venous thromboembolism.
The value of these tests in managing patients with thromboembolic disorders appears limited due to inconclusive data and sensitivity issues.

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