[Polyamines and activity of acid peptide-hydrolases in hyperoxia]

The content of spermidine and spermine polyamines in the rat brain under hyperoxic convulsions and four hours after convulsions decreases sharply. The intraperitoneal administration of polyamines before hyperbaric oxygenation decreased the rate of development of hyperoxic convulsions in rats. In the model experiments polyamines prevented changes in the acid peptide-hydrolase activity in the lysosomal and soluble fractions, which occur under hyperoxia.