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Nesidioblastosis in adults without insular hyperfunction.

P N Karnauchow

    American Journal of Clinical Pathology
    |October 1, 1982
    PubMed
    Summary
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    Minimal nesidioblastosis and ductulo-insular complexes were observed in adult pancreases without insular hyperfunction. These findings suggest developmental variations in pancreatic islet cells, with unclear causative factors.

    Area of Science:

    • Endocrinology
    • Histopathology

    Background:

    • Nesidioblastosis, characterized by islet cell proliferation, is typically associated with hyperinsulinemic hypoglycemia.
    • The presence and significance of nesidioblastosis in individuals without clinical evidence of insular hyperfunction remain incompletely understood.

    Purpose of the Study:

    • To investigate the prevalence of minimal nesidioblastosis and ductulo-insular complexes in adult pancreases without insular hyperfunction.
    • To explore potential demographic associations and developmental patterns of these pancreatic findings.

    Main Methods:

    • Autopsy examination of 207 adult pancreases.
    • Histopathological analysis of pancreatic biopsy specimens.

    Main Results:

    • Minimal nesidioblastosis was detected in 36.7% of autopsy pancreases.

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  • Ductulo-insular complexes and insular cells within acini were found in 10.6% of biopsy specimens.
  • Nesidioblastosis was more prevalent in males (61.8%).

    • Conclusions:

    • The study identified nesidioblastosis and ductulo-insular complexes in a significant proportion of pancreases lacking clinical evidence of insular hyperfunction.
    • These findings suggest asynchronous development and potentially distinct stimuli for islet cell aggregations.
    • Causative factors for these pancreatic alterations were not elucidated in this series.