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Related Experiment Videos

Premedication with intramuscular midazolam: a prospective randomized double-blind controlled study.

H R Vinik, J G Reves, D Wright

    Anesthesia and Analgesia
    |November 1, 1982
    PubMed
    Summary

    Midazolam and hydroxyzine effectively reduced patient anxiety before surgery compared to placebo. Midazolam demonstrated a prompt onset and minimal tissue irritation, making it a safe premedicant for surgical patients.

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    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Preoperative anxiety is a common concern in surgical patients.
    • Effective anxiolytic premedication is crucial for patient comfort and procedural success.

    Purpose of the Study:

    • To compare the efficacy and safety of midazolam and hydroxyzine as premedicants for surgical patients.
    • To evaluate the onset of action and local tissue reactions associated with these agents.

    Main Methods:

    • A randomized, placebo-controlled trial involving 100 ASA physical status I and II surgical patients.
    • Patients received midazolam (0.07 mg/kg), hydroxyzine (1.0 mg/kg), or placebo intramuscularly 60-90 minutes before anesthesia.
    • Anxiety was assessed using the Anxiety Visual Analog Test (AVAT) and an objective observer rating scale.

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    Main Results:

    • Both midazolam and hydroxyzine significantly reduced anxiety compared to placebo (p < 0.05).
    • Peak anxiolytic effect was observed between 30 and 60 minutes post-administration.
    • Hydroxyzine caused mild injection site irritation in 68% of patients, while midazolam caused irritation in 26%.

    Conclusions:

    • Midazolam is an effective and safe premedicant for healthy surgical patients.
    • Midazolam offers a prompt onset of action with minimal local tissue irritation compared to hydroxyzine.