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Captopril in essential hypertension
British Journal of Clinical Pharmacology
|January 1, 1982
Summary
Captopril effectively manages essential hypertension, often with a diuretic. Doses of 150-300 mg are generally adequate for blood pressure control with minimal side effects.
Area of Science:
- Cardiology
- Pharmacology
- Nephrology
Background:
- Essential hypertension affects millions globally, necessitating effective and safe treatment options.
- Current antihypertensive therapies require ongoing evaluation for efficacy and tolerability.
Purpose of the Study:
- To assess the efficacy and tolerability of captopril in patients with essential hypertension.
- To determine optimal dosing strategies for captopril, with or without hydrochlorothiazide.
Main Methods:
- A study involving 41 patients with essential hypertension (stages I-III).
- Patients received captopril monotherapy or combination therapy with hydrochlorothiazide.
- Blood pressure response, plasma renin activity, and safety parameters were monitored.
Main Results:
- 42% of patients responded to captopril alone; 58% required a diuretic.
- No significant correlation was found between drug response and plasma renin activity.
- Captopril was well-tolerated, with mild, transient side effects reported in a few patients. No significant adverse effects on renal function or metabolic parameters were observed.
Conclusions:
- Captopril, at doses of 150-300 mg daily, is effective in controlling blood pressure in most essential hypertension patients.
- Combination therapy with hydrochlorothiazide may be necessary for a significant portion of patients.
- Captopril demonstrates a favorable safety profile for managing essential hypertension.