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Captopril in essential hypertension.

E Rabinad Estrada, M Ingelmo Morin, A Martinez Amenos

British Journal of Clinical Pharmacology

|January 1, 1982

Summary

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Captopril effectively manages essential hypertension, often with a diuretic. Doses of 150-300 mg are generally adequate for blood pressure control with minimal side effects.

Area of Science:

Cardiology
Pharmacology
Nephrology

Background:

Essential hypertension affects millions globally, necessitating effective and safe treatment options.
Current antihypertensive therapies require ongoing evaluation for efficacy and tolerability.

Purpose of the Study:

To assess the efficacy and tolerability of captopril in patients with essential hypertension.
To determine optimal dosing strategies for captopril, with or without hydrochlorothiazide.

Main Methods:

A study involving 41 patients with essential hypertension (stages I-III).
Patients received captopril monotherapy or combination therapy with hydrochlorothiazide.
Blood pressure response, plasma renin activity, and safety parameters were monitored.

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Main Results:

42% of patients responded to captopril alone; 58% required a diuretic.
No significant correlation was found between drug response and plasma renin activity.
Captopril was well-tolerated, with mild, transient side effects reported in a few patients. No significant adverse effects on renal function or metabolic parameters were observed.

Conclusions:

Captopril, at doses of 150-300 mg daily, is effective in controlling blood pressure in most essential hypertension patients.
Combination therapy with hydrochlorothiazide may be necessary for a significant portion of patients.
Captopril demonstrates a favorable safety profile for managing essential hypertension.