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Long-term experience with captopril in severe hypertension.
British Journal of Clinical Pharmacology
|January 1, 1982
Summary
Captopril effectively lowers blood pressure in severe hypertension, particularly renovascular cases. This angiotensin-converting enzyme inhibitor demonstrated long-term efficacy and manageable side effects in patients resistant to other therapies.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Severe hypertension often requires combination therapy.
- Some patients exhibit resistance to standard antihypertensive treatments.
Purpose of the Study:
- To evaluate the long-term efficacy and safety of captopril in severe hypertension.
- To assess captopril's effectiveness in different hypertension subtypes.
Main Methods:
- A study involving 76 patients with severe hypertension resistant to triple therapy.
- Long-term observation of blood pressure reduction and side effects.
Main Results:
- Captopril achieved prompt and sustained reductions in systolic and diastolic blood pressure across all groups.
- Renovascular hypertension patients showed a more significant diastolic pressure decrease.
- Most patients required concomitant diuretics and propranolol; side effects were generally mild, with serious events being rare.
Conclusions:
- Captopril is a potent antihypertensive agent for severe and resistant hypertension.
- It is particularly effective in renovascular hypertension.
- Adverse effects are more common with higher dosages and impaired kidney function.