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Eosinophilic fasciitis.

L A Sibrack, E M Mazur, R Hoffman

    Clinics in Rheumatic Diseases
    |August 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Eosinophilic fasciitis (EF) is a connective tissue disorder presenting as indurated skin plaques, often on extremities. Corticosteroid treatment typically improves clinical and laboratory features, though serious hematological abnormalities can occur.

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    Area of Science:

    • Rheumatology
    • Dermatology
    • Connective Tissue Diseases

    Background:

    • Eosinophilic fasciitis (EF) is a distinct connective tissue disorder characterized by deep fascial inflammation.
    • Clinical presentation includes indurated skin plaques, predominantly on extremities, with peripheral eosinophilia, hypergammaglobulinaemia, and elevated ESR.
    • Distinguishing EF from scleroderma is crucial due to differing prognoses and management.

    Purpose of the Study:

    • To detail the clinical, laboratory, and histopathological features of eosinophilic fasciitis.
    • To discuss associated serious hematological abnormalities in EF.
    • To delineate the similarities and distinctions between eosinophilic fasciitis and scleroderma.

    Main Methods:

    • Review of clinical case data and laboratory findings in patients with eosinophilic fasciitis.

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  • Histopathological examination of affected skin and fascial tissues.
  • Comparative analysis of EF features against scleroderma criteria.

    • Main Results:

    • EF presents with bound-down skin plaques, peripheral eosinophilia, and elevated inflammatory markers.
    • Histopathology reveals abnormalities primarily in the lower subcutis and fascia.
    • Systemic corticosteroids generally lead to clinical improvement, but serious hematological issues can arise.
    • Absence of Raynaud's phenomenon, acral sclerosis, visceral involvement, and antinuclear antibodies are typical differentiating features from scleroderma.

    Conclusions:

    • Eosinophilic fasciitis is a unique disorder with characteristic clinical and histopathological findings.
    • Prompt diagnosis and treatment with corticosteroids are essential for managing EF.
    • Understanding the differences between EF and scleroderma is critical for appropriate patient management and prognosis.