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Estimating population kinetics.

S L Beal, L B Sheiner

    Critical Reviews in Biomedical Engineering
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This review covers methods for estimating population pharmacokinetic model parameters. It addresses variability in drug behavior among individuals, discussing explainable and unexplainable kinetic differences.

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    Area of Science:

    • Pharmacokinetics and Pharmacodynamics
    • Biostatistics
    • Population Modeling

    Background:

    • Population variability in kinetic behavior of endogenous and exogenous substances is significant.
    • Existing models aim to describe interindividual kinetic variability.
    • Understanding this variability is crucial for accurate pharmacokinetic studies.

    Purpose of the Study:

    • To review advanced methods for estimating parameters in population kinetic models.
    • To critically discuss the assumptions underlying these models.
    • To highlight the importance of addressing interindividual variability.

    Main Methods:

    • Review of established and novel parameter estimation techniques.
    • Analysis of model assumptions and their impact on results.

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  • Discussion of methods to account for explainable and unexplainable variability.

    • Main Results:

    • Identification of key methods for population pharmacokinetic parameter estimation.
    • Critical evaluation of model assumptions in the context of biological variability.
    • Emphasis on strategies for handling unexplainable interindividual differences.

    Conclusions:

    • Accurate pharmacokinetic modeling requires robust parameter estimation methods.
    • Addressing interindividual variability is essential for reliable population kinetic characterization.
    • Further research into unexplainable kinetic variability is warranted.