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Phthalate ester testing in the National Toxicology Program's environmental mutagenesis test development program.

E Zeiger, S Haworth, W Speck

    Environmental Health Perspectives
    |November 1, 1982
    PubMed
    Summary
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    Phthalate esters and related chemicals were evaluated for mutagenicity using the Ames Salmonella test. Across three independent laboratories, all tested chemicals were found to be nonmutagenic in this bacterial mutagenicity assay.

    Area of Science:

    • Environmental chemistry
    • Toxicology
    • Genetics

    Background:

    • Phthalate esters are widely used as plasticizers.
    • Concerns exist regarding the potential genotoxicity of phthalates.
    • Assessing chemical mutagenicity is crucial for risk assessment.

    Purpose of the Study:

    • To evaluate the mutagenicity of various phthalate esters and related compounds.
    • To determine if these chemicals induce mutations in bacterial systems.

    Main Methods:

    • Utilized the Ames Salmonella/mammalian microsome test, a standard bacterial mutagenicity assay.
    • Employed a preincubation modification of the test protocol.
    • Conducted blind testing across three independent laboratories for reliability.
    • Used S-9 liver fraction from Aroclor-induced rats and Syrian hamsters for metabolic activation.

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    Main Results:

    • All phthalate esters and related chemicals tested were found to be nonmutagenic.
    • Consistent results were observed across the three participating laboratories.

    Conclusions:

    • Under the conditions tested, the evaluated phthalate esters and related chemicals do not exhibit mutagenic potential in Salmonella typhimurium.
    • The findings suggest a lack of genotoxic activity for these specific compounds in this assay system.