Some aspects of the immunology of pseudotuberculosis

Integral evaluation of some humoral and cellular immunity factors in patients with pseudotuberculosis (Far-East scarlatinoid fever) with varying severity of its course was carried out. Inadequate immune reaction of human organism in response to infection with pseudotuberculosis was established at the level of both specific (sporadic cases of lacking synthesis or poor synthesis of IgM antibodies, lacking synthesis of IgG antibodies) and non-specific factors (incomplete phagocytic reaction). Phagocytosis is higher in monocytes than in neutrophils during pseudotuberculosis. The opsonizing properties of blood serum, the intensity of which increases in the course of disease, are great importance in freeing the organism from bacteria of pseudotuberculosis. The most rapid and technically simplest is the determination of antibodies in blood serum of the patients by means of the reaction of indirect hemagglutination. For this purpose the authors developed a new, highly sensitive, and specific preparation - the dry erythrocyte antigenic diagnostic agent.