[Insulinemia dynamics in thyrotoxicosis]

It was detected that the blood immunoreactive insulin (IRI) level in thyrotoxic patients is changed on an empty stomach and after glucose load and the pancreatic beta-cell response to hyperglycemia is raised. The IRI level decreases depending on the disease severity, but remains sufficiently high in comparison with that of the control, hypersensitivity of the insular apparatus to glucose being persisted. Subtotal strumectomy-produced euthyrosis, developed shortly after elimination of thyroid intoxication, promotes normalization of the phonic insulin blood activity, but hypersensitivity of beta-cells to glucose persists, being accompanied by arising prolonged hyperinsulinemia in these patients after glucose load.