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Endocrine circadian time structure in the aged.

G Y Nicolau, E Haus, D J Lakatua

    Endocrinologie
    |July 1, 1982
    PubMed
    Summary

    Elderly individuals maintain endocrine system circadian rhythms, showing an earlier biological clock activation compared to younger adults. This shift in endocrine rhythms may influence age-related changes and sleep disturbances in older populations.

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    Area of Science:

    • Endocrinology
    • Chronobiology
    • Gerontology

    Background:

    • Circadian rhythms are fundamental to endocrine system function.
    • Age-related changes can impact hormonal regulation and biological timing.
    • Understanding endocrine rhythms in the elderly is crucial for addressing age-associated health issues.

    Purpose of the Study:

    • To investigate and quantify thirteen plasma hormone circadian rhythms in elderly individuals.
    • To compare the endocrine circadian time structure of the aged with younger populations.
    • To explore potential links between altered endocrine rhythms and age-related disturbances like sleep disorders.

    Main Methods:

    • Study involved 50 elderly subjects (25 males, 25 females, aged 57-91).
    • Plasma hormone levels (ACTH, aldosterone, cortisol, etc.) were measured.

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  • Radioimmunoassays and cosinor statistical analysis were employed to evaluate circadian rhythms.

    • Main Results:

    • Circadian rhythms were identified and quantified for all thirteen studied hormones in the elderly cohort.
    • Elderly subjects, as a group, demonstrated a maintained circadian time structure in their endocrine systems.
    • Preliminary comparisons suggest an earlier endocrine system arousal in the aged compared to younger individuals.

    Conclusions:

    • The elderly endocrine system exhibits a group phenomenon of maintained circadian rhythms.
    • An earlier endocrine system activation in old age warrants further investigation.
    • Future studies should consider both circadian and circannual variations to fully understand aging-related endocrine changes.