Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mixed connective tissue disease: an overview.

J P Callen

    Southern Medical Journal
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Mixed connective tissue disease (MCTD) presents overlapping symptoms of autoimmune disorders and antibodies to ribonucleoprotein. This report reviews MCTD

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anti-C1q antibodies in systemic lupus erythematosus.

    Lupus·2014
    Same author

    Hypertrophic lupus erythematosus complicating long-standing systemic lupus erythematosus.

    Lupus·2011
    Same author

    Drug-induced subacute cutaneous lupus erythematosus.

    Lupus·2010
    Same author

    Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus.

    Lupus·2004
    Same author

    Vancomycin-induced linear IgA bullous disease presenting as toxic epidermal necrolysis.

    Clinical and experimental dermatology·2004
    Same author

    Update on the management of cutaneous lupus erythematosus.

    The British journal of dermatology·2004

    Area of Science:

    • Rheumatology
    • Immunology
    • Autoimmune Diseases

    Background:

    • Mixed connective tissue disease (MCTD) exhibits overlapping clinical features of established connective tissue diseases.
    • A key diagnostic marker for MCTD is the presence of antibodies to ribonucleoprotein (anti-RNP).
    • The classification of MCTD within the spectrum of autoimmune rheumatic diseases remains a subject of ongoing debate.

    Purpose of the Study:

    • To comprehensively review the clinical manifestations of MCTD.
    • To analyze the prognostic factors associated with MCTD.
    • To discuss the therapeutic strategies employed in managing MCTD.

    Main Methods:

    • Literature review of existing studies on MCTD.
    • Synthesis of clinical data, prognostic indicators, and treatment outcomes.

    Related Experiment Videos

  • Discussion of diagnostic criteria and classification challenges.

    • Main Results:

    • MCTD is defined by a combination of features from systemic lupus erythematosus, scleroderma, and polymyositis.
    • Anti-RNP antibodies are consistently detected in patients with MCTD.
    • Prognosis varies, with some patients experiencing mild symptoms and others developing severe organ involvement.

    Conclusions:

    • MCTD represents a distinct clinical entity within the autoimmune rheumatic disease spectrum.
    • Early diagnosis and appropriate management are crucial for improving patient outcomes.
    • Further research is needed to fully elucidate the pathogenesis and optimal treatment of MCTD.