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[Renin-angiotensin-aldosterone system with regard to age]
Vutreshni Bolesti
|January 1, 1982
Summary
As people age, the renin-angiotensin-aldosterone system (RAAS) shows reduced activity. This age-related decline impacts plasma renin activity and aldosterone levels, affecting the body
Area of Science:
- Endocrinology
- Gerontology
- Physiology
Background:
- The renin-angiotensin-aldosterone system (RAAS) plays a crucial role in regulating blood pressure and fluid balance.
- Age-related changes in physiological systems are common, but their impact on RAAS function requires further investigation.
Purpose of the Study:
- To investigate the functional state of the RAAS in relation to advancing age.
- To assess the impact of aging on plasma renin activity (PRA), plasma aldosterone (PA), and aldosterone excretion.
Main Methods:
- Examined 97 healthy subjects across three age groups.
- Assessed RAAS function using plasma renin activity (PRA), plasma aldosterone (PA), and aldosterone urine excretion.
- Utilized dynamic tests: orthostatic challenge and a low-sodium (hypo-natriemic) diet.
Main Results:
- RAAS activity significantly decreases with age, evidenced by lower mean PRA, PA, and aldosterone excretion.
- The renin-angiotensin system's response to volume stimuli (orthostatism) is diminished in older adults.
- Sodium excretion reactivity remains preserved in elderly and aged individuals.
Conclusions:
- Advancing age leads to a reduction in overall RAAS activity.
- Older individuals exhibit a blunted response of the renin-angiotensin system to orthostatic stress.
- The sympathetic nervous system's role in age-related RAAS changes is a potential area for further research.