Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional differences in lung function during anaesthesia and intensive care: clinical implications.

G Hedenstierna, J Santesson, L Bindslev

    Acta Anaesthesiologica Scandinavica
    |October 1, 1982
    PubMed
    Summary

    Anaesthesia and acute respiratory failure can cause hypoxemia due to ventilation-perfusion mismatch. Selective PEEP and differential ventilation improve gas exchange and may reduce risks associated with general PEEP.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial.

    JAMA·2019
    Same author

    Tidal changes in PaO<sub>2</sub> and their relationship to cyclical lung recruitment/derecruitment in a porcine lung injury model.

    British journal of anaesthesia·2019
    Same author

    Specific anesthesia-induced lung volume changes from induction to emergence: a pilot study.

    Acta anaesthesiologica Scandinavica·2017
    Same author

    Atelectasis is inversely proportional to transpulmonary pressure during weaning from ventilator support in a large animal model.

    Acta anaesthesiologica Scandinavica·2017
    Same author

    Erratum to Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial.

    Trials·2017
    Same author

    Protective intraoperative ventilation with higher versus lower levels of positive end-expiratory pressure in obese patients (PROBESE): study protocol for a randomized controlled trial.

    Trials·2017

    Area of Science:

    • Anesthesiology
    • Respiratory Physiology
    • Critical Care Medicine

    Background:

    • Anesthesia and acute respiratory failure often lead to decreased functional residual capacity (FRC).
    • Reduced FRC causes airway closure in dependent lung regions and ventilation-perfusion (V/Q) mismatch, potentially leading to hypoxemia.
    • Conventional positive end-expiratory pressure (PEEP) can worsen V/Q mismatch and impede cardiac output.

    Purpose of the Study:

    • To explore methods for improving ventilation-perfusion matching during mechanical ventilation.
    • To evaluate the efficacy of differential ventilation and selective PEEP in enhancing gas exchange.
    • To compare the potential benefits of these techniques over general PEEP.

    Main Methods:

    • Investigated lateral positioning to optimize V/Q matching.

    Related Experiment Videos

  • Utilized differential ventilation to independently control ventilation for each lung based on perfusion.
  • Applied PEEP selectively to the dependent lung (selective PEEP).

    • Main Results:

    • Differential ventilation and selective PEEP demonstrated improved matching of ventilation and perfusion.
    • Observed a 50-100% increase in partial pressure of oxygen in arterial blood (PaO2) in patients studied.
    • These methods may reduce intrathoracic pressure, lung expansion, and interference with total lung blood flow compared to general PEEP.

    Conclusions:

    • Differential ventilation and selective PEEP offer promising strategies for improving gas exchange in patients with acute respiratory conditions.
    • These techniques may mitigate risks such as barotrauma and hemodynamic compromise associated with general PEEP.
    • Further studies are warranted to fully elucidate the clinical utility of these advanced ventilation strategies.