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Total atrioventricular block with syncopes complicating carbamazepine therapy
Acta Medica Scandinavica
|January 1, 1982
Summary
Carbamazepine can cause intermittent atrioventricular block and asystole, leading to Stokes-Adams attacks. Pacemaker insertion and drug withdrawal are crucial for managing this serious cardiac side effect.
Area of Science:
- Cardiology
- Clinical Pharmacology
Background:
- Carbamazepine is an anticonvulsant and mood-stabilizing drug.
- Adverse cardiac events are potential side effects of carbamazepine therapy.
Observation:
- A case of intermittent total atrioventricular block with asystole and Stokes-Adams attacks was observed.
- These symptoms were directly linked to carbamazepine administration.
Findings:
- The diagnosis was confirmed by readministering carbamazepine after pacemaker implantation.
- This demonstrates a causal relationship between carbamazepine and the cardiac conduction abnormality.
Implications:
- Patients on carbamazepine experiencing syncope require thorough cardiac conduction evaluation.
- This highlights the importance of monitoring for cardiac adverse effects during carbamazepine treatment.