Related Experiment Video

Updated: Aug 16, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Shunt nephritis progressing to chronic renal failure

M Schoeneman, B Bennett, I Greifer

    American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
    |November 1, 1982
    PubMed

    Insights

    Shunt nephritis, an immune-related kidney disease from infected shunts, can cause irreversible renal damage if not diagnosed and treated promptly. Early detection and antibiotics are crucial for managing this serious condition in children.

    Area of Science:

    • Nephrology
    • Immunology
    • Pediatric Medicine

    Background:

    • Shunt nephritis is an immune-complex mediated glomerular disease.
    • It is linked to infected ventriculo-jugular shunts used for hydrocephalus treatment.

    Observation:

    • Prompt diagnosis and antibiotic therapy typically lead to recovery of renal function.
    • This case highlights a child with delayed diagnosis and irreversible renal insufficiency.

    Findings:

    • Shunt nephritis can progress to severe, irreversible kidney damage.
    • Delayed treatment significantly worsens patient outcomes.

    Implications:

    • A high index of suspicion for shunt nephritis is essential in children with ventriculo-jugular shunts.
    • Early intervention is critical to prevent permanent renal damage and preserve kidney function.

    More Related Videos

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

    5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

    Published on: April 4, 2025

    Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury07:02

    Mouse Model of Acute to Chronic Kidney Disease Transition Induced by Renal Ischemia/Reperfusion Injury

    Published on: February 10, 2026

    Related Concept Videos

    Nephrons01:10

    Nephrons

    The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
    Dialysis01:27

    Dialysis

    Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
    Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
    Acute Kidney Injury II: Pathophysiology01:29

    Acute Kidney Injury II: Pathophysiology

    Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
    Acute Kidney Injury III: Clinical Manifestations01:29

    Acute Kidney Injury III: Clinical Manifestations

    Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
    Chronic Kidney Disease I: Introduction01:25

    Chronic Kidney Disease I: Introduction

    Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
    Diabetic Nephropathy01:28

    Diabetic Nephropathy

    Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...