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Invited review: guidance cue patterns and cell migration in multicellular organisms
Cell Motility
|January 1, 1980
Summary
Guidance cues, like molecules or surfaces, direct cell migration in organisms. These cues form broad gradients or discrete routes, dictating complex cell movement patterns.
Area of Science:
- Cell biology
- Developmental biology
- Neuroscience
Background:
- Multicellular organisms utilize guidance cues for cell and cell process orientation.
- These cues are essential for orchestrating complex in vivo migration routes.
Purpose of the Study:
- To elucidate the organizational patterns of guidance cues in vivo.
- To understand how these patterns influence cell migration routes.
Main Methods:
- Analysis of existing literature on cell migration and guidance cues.
- Categorization of guidance cue patterns based on their spatial distribution.
Main Results:
- Guidance cues are organized into two primary patterns: broad gradients and discrete routes.
- Examples include diffuse chemotactic gradients (broad) and substrate pathways like axon surfaces (discrete).
Conclusions:
- The spatial organization of guidance cues directly determines the complex migratory pathways of cells and cell processes.
- Understanding these patterns is crucial for comprehending developmental processes and tissue organization.