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Related Experiment Videos

Insulin delivery systems: do they need a glucose sensor?

A M Albisser

    Diabetes Care
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    New insulin infusion systems for diabetes mellitus show promise. Portable systems achieve metabolic normalization without continuous glucose sensing, even during exercise, offering a path toward ideal diabetes control.

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    Area of Science:

    • Biomedical Engineering
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Diabetes mellitus management requires precise glucose control.
    • Continuous insulin infusion systems aim to mimic physiological insulin secretion.
    • Existing systems face challenges in long-term efficacy and user convenience.

    Purpose of the Study:

    • To evaluate novel systems for continuous insulin infusion in diabetes mellitus.
    • To compare the efficacy of closed-loop and open-loop insulin delivery systems.
    • To assess the impact of these systems on metabolic control and hormonal balance.

    Main Methods:

    • Short-term studies utilized bedside closed-loop systems (artificial B-cell).
    • Long-term studies in animals and humans employed portable, external open-loop insulin delivery systems.

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  • Metabolic parameters, fuel substrates, and hormone levels were monitored.

    • Main Results:

    • Bedside closed-loop systems normalized blood glucose in fasting and fed states.
    • Portable open-loop systems achieved similar metabolic normalization without continuous glucose sensing.
    • Metabolic control was maintained during physical exercise with minimal risk of hypoglycemia.

    Conclusions:

    • Portable open-loop insulin delivery systems offer a promising approach for long-term diabetes management.
    • These systems can achieve significant metabolic normalization without continuous glucose monitoring.
    • Further research will determine if ideal metabolic control is achievable with or without metabolite sensors.