Hormonal response to LH-RH application in normal women

The postovulatory effects of pharmacological doses of LH-RH on progesterone and LH plasma concentrations have been demonstrated. LH-RH injected on the 16th and 18th day of the menstrual cycle induces the discharge of LH; the second application results in a weaker discharge, indicating that the pituitary stores are exhausted. A LH-RH injection induces a decrease of the plasma progesterone concentration which becomes evident after a delay of 26 hours. A statistically significant correlation between LH and progesterone plasma concentrations was obtained 26 h after the administration of LH-RH.