Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Islet electrical pacemaker response to alpha-adrenergic stimulation.

D L Cook, E Perara

    Diabetes
    |November 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interstellar ^{60}Fe on the Surface of the Moon.

    Physical review letters·2016
    Same author

    The foundational model of anatomy: a template for the symbolic representation of multi-scale physiological functions.

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
    Same author

    A simple method for assessing muscle function in common marmosets.

    Laboratory animals·2005
    Same author

    Evaluation of total phosphorus and total nitrogen methods in pulp mill effluents.

    Water science and technology : a journal of the International Association on Water Pollution Research·2004
    Same author

    Early mycosis fungoides: can the diagnosis be made reliably?

    Advances in anatomic pathology·2001
    Same author

    A basis for a visual language for describing, archiving and analyzing functional models of complex biological systems.

    Genome biology·2001
    Same journal

    Females Are Completely Resistant to Semaglutide-Induced Muscle Loss in ob/ob Mice.

    Diabetes·2026
    Same journal

    Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.

    Diabetes·2026
    Same journal

    Targeting the ADA/ADO Axis Rescues β-Cell Failure in Type 2 Diabetes.

    Diabetes·2026
    Same journal

    TXNIP Is Positioned as a Key Mediator of Hyperglycemia-Induced Vascular Senescence.

    Diabetes·2026
    Same journal

    Sex Differences in ER Stress Pathways Are a Key Determinant of β-Cell Proliferation and Resilience.

    Diabetes·2026
    Same journal

    The Mechanism of TNF-α Combined With High Glucose in Regulating Calnexin Aggravates Endoplasmic Reticulum Stress in Endothelial Cell Injury of Diabetic Retinopathy.

    Diabetes·2026
    See all related articles

    Epinephrine dose-dependently suppressed glucose-stimulated electrical activity in mouse pancreatic islets. This suggests distinct pathways regulate electrical rhythms and that electrical activity can persist without insulin release.

    Area of Science:

    • Endocrinology
    • Cell Physiology
    • Neuroendocrinology

    Background:

    • Pancreatic islets regulate blood glucose via insulin secretion.
    • Adrenergic stimulation influences islet cell function.
    • Understanding islet cell electrical activity is crucial for metabolic control.

    Purpose of the Study:

    • To investigate the effects of epinephrine on pancreatic islet cell electrical activity.
    • To characterize the dose-dependent response of islets to adrenergic stimulation.
    • To explore the relationship between electrical activity and insulin release.

    Main Methods:

    • Isolated mouse islets of Langerhans were perifused under steady glucose conditions (200 mg/dl).
    • Membrane potentials were recorded.

    Related Experiment Videos

  • Varying doses of epinephrine HCl (5–10,000 nM) were applied in a controlled manner.

    • Main Results:

    • Epinephrine exhibited a dose-dependent suppression of glucose-induced electrical activity.
    • Low epinephrine concentrations (50–100 nM) significantly reduced plateau fraction and frequency.
    • Higher epinephrine concentrations showed minimal additional effect, and electrical activity persisted even at high doses.

    Conclusions:

    • Adrenergic stimulation by epinephrine inhibits islet cell electrical activity through a distinct mechanism compared to glucose reduction.
    • Islet electrical activity and calcium uptake can occur independently of insulin release.
    • Multiple pathways likely control the electrical rhythm of pancreatic islets.