Related Experiment Video
Updated: Feb 18, 2026

Use of the Invertebrate Galleria mellonella as an Infection Model to Study the Mycobacterium tuberculosis Complex
Published on: June 30, 2019
Mycobacterium bovis isolated from a dusky langur with granulomas in the intestine
Abstract:
Tubercles were seen in the spleen of a male dusky langur (Presbytis obscurus) on laparotomy. Subsequently, tuberculous lesions in the intestine, lungs, and a hilar lymph node were observed on necropsy of the monkey. Histologic examinations of these tissues revealed granulomas, and acid-fast bacilli were observed within granulomas in replicate sections that were stained with auramine-O. An acid-fast organism was isolated and identified as Mycobacterium bovis. Guinea pigs and rabbits inoculated intraperitoneally with the organism developed granulomas in the lungs, liver, and spleen. Lesions did not develop in chickens inoculated with the culture.
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