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Immunological factors in Peromyscus speciation.

W D Dawson, S C Reuning, M F Finlay

    The Journal of Experimental Zoology
    |November 20, 1982
    PubMed
    Summary
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    Immunological differences between deermice (Peromyscus maniculatus) and oldfield mice (P. polionotus) impact hybrid offspring size and survival. These immune disparities may cause reproductive isolation in closely related species.

    Area of Science:

    • Immunogenetics
    • Developmental Biology
    • Reproductive Biology

    Background:

    • Reciprocal F1 hybrids of Peromyscus maniculatus and P. polionotus exhibit significant differences in fetal, placental, and adult size.
    • Hybrid fetal mortality is linked to larger conceptus size.

    Purpose of the Study:

    • To investigate the relationship between skin graft rejection times and body size in Peromyscus hybrids.
    • To determine if immunological disparities contribute to size variations and hybrid mortality.

    Main Methods:

    • Exchanged skin grafts between and within Peromyscus species.
    • Pre-immunized female Peromyscus maniculatus with paternal spleen cell antigens.
    • Compared graft retention times with fetal and adult body size data.

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    Main Results:

    • Interspecific skin grafts rejected significantly earlier than intraspecific grafts.
    • Pre-immunization with paternal antigens reduced hybrid offspring size.
    • Data supported the hypothesis of immunological disparity influencing hybrid size.

    Conclusions:

    • Immunological differences between Peromyscus species can cause substantial size variations in reciprocal hybrids.
    • Multiple minor histocompatibility factors likely contribute to placental size and fetal mortality.
    • Physiological reproductive isolation may arise from interspecific immunological disparities.