Influence of dietary vitamin E on platelet thromboxane A2 and vascular prostacyclin I2 in rabbit

Rabbits were maintained on vitamin E-deficient and vitamin E-supplemented diets. Thrombin- and collagen-induced thromboxane A2 production were significantly elevated in vitamin E-deficient platelets. Conversion of arachidonic acid to platelet thromboxane A2 was unchanged between the two groups of animals. Prostacyclin I2 production in the aortas from vitamin E-deficient rabbits was significantly elevated.