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Updated: Aug 16, 2026
11:49
Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
[Immunosuppressive therapy following kidney transplantation]
Der Urologe. Ausg. A
|September 1, 1982
Summary
Immunosuppressive therapy is crucial for allogeneic organ transplants, often using a combination of drugs. Careful dosage management is advised to minimize complications, particularly after kidney transplantation.
Area of Science:
- Immunology
- Transplantation Medicine
- Pharmacology
Context:
- Allogeneic organ transplantation necessitates immunosuppressive therapy to prevent rejection.
- Current immunosuppressive strategies often involve combined drug regimens.
- Complications post-transplantation are frequently linked to immunosuppressive treatments.
Purpose:
- To review various non-specific immunosuppressive methods used in organ transplantation.
- To discuss the efficacy and limitations of different immunosuppressive agents.
- To highlight the importance of managing immunosuppressive therapy to reduce complications.
Summary:
- Standard immunosuppression combines glucocorticosteroids, azathioprine, and antilymphocyte globulin.
- Cyclosporine A offers potential improvements in immunosuppression.
- Alternative methods like lymph node radiation or plasmapheresis have limited applicability due to risks and complexity.
- Complications after kidney transplantation are often side effects of immunosuppression.
- Advising low-dose immunosuppressants and dose limitation during acute rejection is recommended.
Impact:
- Informs clinical practice regarding immunosuppressive therapy choices.
- Emphasizes the need for optimized immunosuppression to improve patient outcomes.
- Guides future research into safer and more effective immunosuppressive strategies.
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