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Rabies-related viruses.

R E Shope

    The Yale Journal of Biology and Medicine
    |May 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Africa harbors five rabies-related viruses, some found in insects and others closely related to rabies. These viruses, including Mokola and Lagos bat viruses, highlight public health concerns and Africa

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    Area of Science:

    • Virology
    • Epidemiology
    • Public Health

    Background:

    • Rabies virus and related viruses pose significant public health risks globally.
    • Africa is recognized as a region with high antigenic diversity for rabies-related viruses.
    • Understanding the origins and spread of these viruses is crucial for disease control.

    Purpose of the Study:

    • To identify and characterize rabies-related viruses in Africa.
    • To investigate the antigenic relationships between these viruses and the rabies virus.
    • To assess the public health implications and evolutionary origins of rabies in Africa.

    Main Methods:

    • Isolation and identification of five distinct rabies-related viruses from various hosts (insects, shrews, bats, humans) in African countries.

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  • Antigenic characterization to determine the relatedness of these viruses to the classical rabies virus.
  • Epidemiological investigation of a rabies-related virus outbreak in domestic animals in Zimbabwe.

    • Main Results:

    • Two insect-specific viruses (Obodhiang, Kotonkan) show distant relation to rabies virus.
    • Three viruses (Mokola, Lagos bat, Duvenhage) are antigenically closer to rabies virus.
    • A significant epizootic of a rabies-related virus occurred in dogs and cats in Zimbabwe, demonstrating public health relevance.

    Conclusions:

    • Africa is likely the ancestral origin of the rabies virus, evidenced by its greatest antigenic diversity.
    • Insect-borne viruses may represent the ancestral form of the rabies virus.
    • Further research is needed to understand the evolution and establishment of rabies in the New World, particularly in bats.