Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

C-peptide.

J B Hoekstra, H J van Rijn, D W Erkelens

    Diabetes Care
    |July 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    C-peptide, a byproduct of insulin production, is measured in blood and urine to assess pancreatic B-cell function. Its levels help differentiate causes of hyperinsulinism and guide diabetes treatment.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Lipids and apoproteins in relation to participation in organized sport activities and pubertal development in boys.

    American journal of human biology : the official journal of the Human Biology Council·2017
    Same author

    Bromocriptine and insulin sensitivity in lean and obese subjects.

    Endocrine connections·2016
    Same author

    Dopaminergic Effects on Brown Adipose Tissue (DEBAT): A prospective physiological study.

    Diabetes & metabolism·2016
    Same author

    Differential effect of female gender on coronary artery disease and peripheral artery disease.

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2015
    Same author

    The continuous postprandial state of man and its influence on atherosclerosis.

    Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·2015
    Same author

    The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus.

    Journal of thrombosis and haemostasis : JTH·2012

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Clinical Chemistry

    Background:

    • C-peptide is a polypeptide derived from proinsulin cleavage in pancreatic B-cells.
    • It is secreted equimolarly with insulin and primarily cleared by the kidneys, with a small fraction excreted in urine.
    • C-peptide assays are crucial for evaluating B-cell function and insulin secretion.

    Purpose of the Study:

    • To provide a comprehensive overview of C-peptide's origin, secretion, metabolism, and measurement.
    • To discuss the clinical applications and research value of C-peptide measurements.
    • To highlight potential sources of error in C-peptide assays.

    Main Methods:

    • Radioimmunoassay (RIA) is the primary method for measuring C-peptide in serum and urine.
    • Glucagon is cited as a simple secretagogue for evaluating B-cell function.

    Related Experiment Videos

  • Analysis of assay limitations including standard, tracer, antiserum specificity, and C-peptide degradation.

    • Main Results:

    • C-peptide is secreted equimolarly with insulin and minimally extracted by the liver.
    • Kidney function significantly influences C-peptide clearance and urinary excretion.
    • Accurate C-peptide measurement requires careful consideration of assay-related errors.

    Conclusions:

    • C-peptide measurements are valuable for distinguishing endogenous from exogenous hyperinsulinism.
    • It aids in determining the necessity of insulin therapy in diabetic patients.
    • C-peptide is indispensable in clinical research for monitoring B-cell activity in diabetes.