Carprofen in osteoarthrosis

Two randomized double-blind trials with carprofen in osteoarthrosis were performed. The first compared carprofen with ibuprofen in 2 groups of 10 patients for 8 weeks and the second compared carprofen administered in two different schedules (100 mg in the morning plus 200 mg in the evening versus 100 mg 3 times daily) for 4 weeks, also in 2 groups of 10 cases. The trials indicate that carprofen is effective and well tolerated. In the first trial efficacy shows a small trend in favour of carprofen and in the second a slight superiority of the b.i.d. schedule as compared to t.i.d.