Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does translational ambiguity increase during cell differentiation?

M Picard-Bennoun

    FEBS Letters
    |November 29, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Change in cytoplasmic ribosome properties during gametogenesis in the alga Chlamydomonas reinhardtii.

    Current genetics·2013
    Same author

    At least seven ribosomal proteins are involved in the control of translational accuracy in a eukaryotic organism.

    Journal of molecular biology·1986
    Same author

    Introns, protein syntheses and aging.

    FEBS letters·1985
    Same author

    Analysis of revertants of a ribosomal mutation in Podospora anserina: evidence for new ribosomal mutations which confer hypersensitivity to paromomycin.

    Biochemical genetics·1982
    Same author

    Mutations affecting translational fidelity in the eucaryote Podospora anserina: characterization of two ribosomal restrictive mutations.

    Molecular & general genetics : MGG·1981
    Same author

    Search for ribosomal mutants in Podospora anserina: genetic analysis of cold-sensitive mutants.

    Genetical research·1980
    Same journal

    Identification of a Shiga toxin A-derived peptide internalized into Gb3 receptor-bearing cells via interaction with the Shiga toxin B subunit.

    FEBS letters·2026
    Same journal

    The dual role of lectins in cancer-immunotherapy tools and therapeutic targets.

    FEBS letters·2026
    Same journal

    Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression.

    FEBS letters·2026
    Same journal

    Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior.

    FEBS letters·2026
    Same journal

    α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.

    FEBS letters·2026
    Same journal

    Modelling stem cell differentiation related processes-A practical overview for biologists.

    FEBS letters·2026
    See all related articles

    Translational ambiguity, or errors in protein synthesis, may increase during specific life cycle stages in fungi, yeast, and algae. This controlled increase in errors could be essential for producing regulatory proteins during cellular differentiation.

    Area of Science:

    • Molecular Biology
    • Cellular Biology
    • Genetics

    Background:

    • Observations in Podospora anserina suggest dynamic changes in translational fidelity.
    • Similar phenomena may occur in other model organisms like yeast (Saccharomyces cerevisiae) and algae (Chlamydomonas reinhardii).

    Purpose of the Study:

    • To investigate the potential role of increased translational ambiguity in cellular processes.
    • To explore the necessity of altered translational properties during specific life cycle stages.

    Main Methods:

    • Comparative analysis of translational apparatus properties across different species.
    • Hypothetical modeling of the effects of increased misreading on protein synthesis.

    Main Results:

    Related Experiment Videos

  • Evidence suggests translational ambiguity can increase at critical life cycle points.
  • This increase appears conserved across diverse eukaryotic organisms.

    • Conclusions:

    • A controlled rise in translational misreading may be a conserved mechanism.
    • This process could facilitate the synthesis of regulatory proteins required for cellular differentiation.