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Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
Immunosuppression by avirulent, pseudohyphal forms of Cryptococcus neoformans
Abstract:
Our previous reports have shown that animals inoculated for 8 weeks with 1 X 10(5) pseudohyphal, avirulent C. neoformans exhibited prolonged survival upon challenge with virulent cryptococci. This paper described a transient phase of immunosuppression which occurs during the initial weeks of the immunization protocol. Animals injected with pseudohyphal organisms had depressed responses to T and B-cell mitogens. In addition, they had lowered responses to immunization with sheep erythrocytes. Both humoral and cell mediated responses were affected.
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