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Immunohistochemistry on Paraffin Sections of Mouse Epidermis Using Fluorescent Antibodies
Published on: January 8, 2008
[Localization of apoprotein B in human dermis. A study using optical and electronic immunoprocedures]
La Nouvelle Presse Medicale
|November 27, 1982
Summary
Apolipoprotein B (apo B), a key component of low-density lipoproteins, is found in human skin fibroblasts and collagen. Increased dermal apo B correlates with coronary artery disease severity.
Area of Science:
- Biochemistry
- Immunohistochemistry
- Dermatology
Context:
- Low-density lipoproteins (LDL) play a role in atherosclerosis.
- Apolipoprotein B (apo B) is the primary protein in LDL.
- The presence and distribution of apo B in dermal tissue are not well understood.
Purpose:
- To investigate the structural localization of apo B in human dermis.
- To compare apo B distribution in the dermis of patients with and without coronary artery disease.
Summary:
- Apo B was localized in human dermal fibroblasts and along collagen fibers using immunofluorescence and immunoperoxidase techniques.
- Dermal areas positive for apo B were significantly more abundant in patients with coronary artery disease compared to healthy controls.
- These findings align with biochemical data showing parallel apo B concentrations in the aorta and skin, varying with atheromatous lesion severity.
Impact:
- This study provides insights into the structural role of apo B in the skin.
- The findings suggest a potential link between dermal apo B deposition and the progression of coronary artery disease.
- Dermal apo B may serve as a biomarker for cardiovascular health.
