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Related Experiment Videos

Elevated plasma vasopressin concentrations during endotoxin and E. coli shock.

M F Wilson, D J Brackett, P Tompkins

    Advances in Shock Research
    |January 1, 1981
    PubMed
    Summary

    During endotoxin and E. coli shock, plasma vasopressin levels significantly increased in dogs and baboons. These elevated vasopressin concentrations correlated with decreased cardiac output and arterial blood pressure.

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    Area of Science:

    • Physiology
    • Endocrinology
    • Pharmacology

    Background:

    • Vasopressin plays a crucial role in regulating blood pressure and fluid balance.
    • Endotoxin and E. coli infections can trigger severe physiological responses, including circulatory shock.

    Purpose of the Study:

    • To investigate plasma vasopressin concentrations during endotoxin and E. coli-induced shock.
    • To correlate vasopressin levels with hemodynamic changes during shock.

    Main Methods:

    • Radioimmunoassay was used to measure plasma vasopressin concentrations.
    • Experiments were conducted on dogs and baboons subjected to endotoxin or E. coli infusion.

    Main Results:

    • Plasma vasopressin levels were markedly elevated, often exceeding 500 pg/ml in dogs and 300 pg/ml in baboons.

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  • Elevated vasopressin concentrations were observed as early as 15 minutes after shock induction, preceding significant hypotension.
  • Higher vasopressin levels correlated with decreased cardiac output and reduced arterial blood pressure.

    • Conclusions:

    • Endotoxin and E. coli shock induce significant elevations in plasma vasopressin.
    • Elevated vasopressin is an early response to shock and is associated with critical hemodynamic alterations.