Jove
Visualize
Contact Us

Related Experiment Videos

Edema formation in the newborn lung.

R D Bland

    Clinics in Perinatology
    |October 1, 1982
    PubMed
    Summary

    Neonatal pulmonary edema, a cause of infant respiratory distress, often stems from increased lung microcirculation pressure. Therapeutic measures can reduce risks by managing fluid pressure and preventing lung injury.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Methods for retrovirus-mediated gene transfer to fetal lung.

    Methods in molecular medicine·2014
    Same author

    Reduced endothelial nitric oxide synthase in lungs of chronically ventilated preterm lambs.

    American journal of physiology. Lung cellular and molecular physiology·2001
    Same author

    Loss of liquid from the lung lumen in labor: more than a simple "squeeze".

    American journal of physiology. Lung cellular and molecular physiology·2001
    Same author

    Chronic lung injury in preterm lambs: abnormalities of the pulmonary circulation and lung fluid balance.

    Pediatric research·2000
    Same author

    Inhaled nitric oxide: a premature remedy for chronic lung disease?

    Pediatrics·1999
    Same author

    Chronic lung injury in preterm lambs. Disordered respiratory tract development.

    American journal of respiratory and critical care medicine·1999
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Neonatology
    • Pediatric Respiratory Medicine
    • Critical Care

    Background:

    • Pulmonary edema is a significant cause of respiratory distress in newborn infants.
    • It is associated with conditions like perinatal asphyxia, heart failure, and bronchopulmonary dysplasia.
    • Neonatal pulmonary edema commonly arises from increased pulmonary microcirculation pressure.

    Purpose of the Study:

    • To review the causes and contributing factors of neonatal pulmonary edema.
    • To highlight the pathophysiological mechanisms involved in fluid accumulation in the lungs.
    • To discuss potential therapeutic strategies for risk reduction.

    Main Methods:

    • Literature review of causes and mechanisms of neonatal pulmonary edema.
    • Analysis of factors contributing to increased pulmonary microvascular pressure.
    • Examination of conditions predisposing to fluid accumulation and lung injury.

    Main Results:

    • Increased pulmonary microcirculation pressure is a key factor, linked to hypoxia, heart failure, and excessive fluid infusions.
    • Hypoproteinemia, especially in premature infants, and lymphatic obstruction contribute to edema.
    • Endothelial injury from infection or oxygen exposure and epithelial leaks also play a role.

    Conclusions:

    • Neonatal pulmonary edema results from complex interactions involving pressure, protein concentration, and lung injury.
    • Therapeutic strategies should focus on reducing fluid filtration pressure and increasing plasma protein osmotic pressure.
    • Preventing or mitigating lung injury is crucial for reducing the incidence and severity of neonatal pulmonary edema.

    Related Experiment Videos