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Related Experiment Videos

Autoantibodies in the BB/W rat.

A A Like, M C Appel, A A Rossini

    Diabetes
    |September 1, 1982
    PubMed
    Summary

    The BioBreeding/Worcester (BB/W) rat, a model for autoimmune diabetes, frequently develops autoantibodies. This suggests an immune system defect, not altered tissues, causes this rat

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    Area of Science:

    • Immunology
    • Endocrinology
    • Animal Models

    Background:

    • The BioBreeding/Worcester (BB/W) rat spontaneously develops autoimmune diabetes mellitus and lymphocytic thyroiditis.
    • Features like protection by antilymphocyte serum, neonatal bone marrow transfusions, and thymectomy support an immunologic pathogenesis.
    • The BB/W rat serves as a critical model for studying autoimmune diseases.

    Purpose of the Study:

    • To investigate immune dysregulation in the BB/W rat colony.
    • To survey for autoantibodies against various tissue and cell constituents.
    • To elucidate the underlying pathogenesis of the BB/W syndrome.

    Main Methods:

    • Surveying the BB/W rat colony for autoantibodies.
    • Testing for antibodies against smooth muscle, thyroid colloid, parietal cells, islet cells, and adrenal tissues.
    • Analyzing the frequency of autoantibodies in diabetic and normoglycemic offspring.

    Main Results:

    • High frequency of anti-smooth muscle and anti-thyroid colloid antibodies in diabetic BB/W rats and their normoglycemic offspring.
    • Lower frequency of anti-parietal cell antibodies.
    • Absence of islet cell cytoplasmic and adrenal antibodies detected.

    Conclusions:

    • The BB/W rat exhibits widespread autoantibody production, indicating immune dysregulation.
    • The data strongly suggest an abnormal immune regulatory system as the primary defect.
    • This contrasts with the

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