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Changes in F wave size during dentatotomy.

J E Fox, E R Hitchcock

    Journal of Neurology, Neurosurgery, and Psychiatry
    |December 1, 1982
    PubMed
    Summary
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    Mean F wave size, a measure of motoneuron excitability, decreased after electrical stimulation or lesions in the dentate nucleus during dentatotomy for spasticity relief. These effects were observed on both the same and opposite sides of the body.

    Area of Science:

    • Neuroscience
    • Clinical Neurology
    • Motor Control Research

    Background:

    • Spasticity is a common neurological condition characterized by increased muscle tone.
    • Motoneuron excitability plays a crucial role in the pathophysiology of spasticity.
    • Dentatotomy is a surgical procedure targeting the dentate nucleus to alleviate spasticity.

    Purpose of the Study:

    • To investigate the effect of dentate nucleus manipulation on motoneuron excitability.
    • To assess the utility of F wave size as a biomarker for monitoring changes in motoneuron excitability during dentatotomy.

    Main Methods:

    • Utilized mean F wave size as an indicator of motoneuron excitability.
    • Applied electrical stimulation to the dentate nucleus.
    • Created lesions within the dentate nucleus during dentatotomy procedures.

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  • Monitored both ipsilateral and contralateral responses.

    • Main Results:

    • Electrical stimulation of the dentate nucleus led to a reduction in mean F wave size.
    • Production of lesions in the dentate nucleus also resulted in decreased mean F wave size.
    • Both ipsilateral and contralateral motoneuron excitability were affected.

    Conclusions:

    • Dentate nucleus stimulation and lesioning reduce motoneuron excitability.
    • Mean F wave size can serve as a reliable measure to monitor these neurophysiological changes.
    • Findings support the role of the dentate nucleus in modulating motor pathways relevant to spasticity.