Augmentation of peritoneal clearance by dipyridamole

We performed a double blind crossover trial in which dipyridamole was administered to ten patients undergoing intermittent peritoneal dialysis at 2 liters/hour (10 min infusion, 30 min intraperitoneal dwell of dialysate and 20 min drainage of dialysate). After the patients received the drug for 3 days at a dose of 75 mg three times daily, peritoneal inulin clearance increased by 1.2 ml/min (P less than 0.05), and glucose absorption increased by 12.1 g (P less than 0.05). The mechanism of the observed drug-induced effects is unknown.