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Tick-borne fever: leucocyte migration inhibition
Veterinary Microbiology
|November 1, 1982
Summary
Infection with Cytoecetes phagocytophila reduces white blood cell migration in sheep, even without antigen. Soluble factors during infection cause this inhibition, which resolves after parasitaemia clears.
Area of Science:
- Veterinary immunology
- Parasitology
- Cellular immunology
Background:
- Cytoecetes phagocytophila is an intracellular bacterium that infects sheep.
- Leukocyte migration is a key component of the immune response.
Purpose of the Study:
- To investigate the effect of Cytoecetes phagocytophila infection on leukocyte migration in sheep.
- To identify the mechanisms underlying migration inhibition during infection.
Main Methods:
- In vitro migration assays of peripheral leukocytes from infected and control sheep.
- Analysis of soluble factors in serum from infected sheep.
Main Results:
- Infection with C. phagocytophila reduced leukocyte migration in vitro, independent of antigen presence.
- Migration inhibition was associated with parasitaemia and mediated by soluble factors from infected sheep.
- Antigen stimulation was required for migration inhibition after the resolution of parasitaemia.
Conclusions:
- Soluble factors produced during C. phagocytophila infection impair leukocyte migration.
- The immune response to C. phagocytophila involves complex modulations of leukocyte function.