Conditioning and the kindling model of epilepsy

Since the development of the kindling preparation there has been much speculation on the contribution of conditioning mechanisms in accounting for the phenomenon. Two recent reports have described attempts to establish conditioned responses utilizing the kindling model. We suggest that the conclusion of uncondition-ability asserted by Wyler & Heavner (1979) is not warranted because of serious misunderstandings relating to the concepts and techniques that are central to both neurophysiological and conditioning theory. We further suggest that the results of their retardation effect can be better interpreted as positive evidence for the successful establishment of conditioning. With respect to the findings by Janowsky et al. (1980), we regard their sample size (2 animals undergoing simultaneous kindling and conditioning and one animal beginning conditioning following kindling) as inadequate for a conclusive demonstration of the success they report. Both studies, however, are seen as substantive contributions, insofar as they introduce this important perspective in kindling research, that can be expected to occupy a major role in the future developments of basic and clinical epileptology.