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Updated: Sep 21, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
10:18

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

Prolymphocytic leukaemia

D Catovsky

    Nouvelle Revue Francaise D'Hematologie
    |January 1, 1982
    PubMed

    A review of the main features of prolymphocytic leukaemia, based on 80 cases studied by the author since 1974, is presented. Prolymphocytes have a B-cell membrane phenotype with strong expression of surface Ig in 81% of cases (B-PLL) whilst the rest have T-cell markers (T-PLL). Both forms of the disease have distinct laboratory and clinical findings. T-PLL has a more aggressive course with a median survival of 7 months (24 months in B-PLL). Ultrastructural analysis demonstrates larger lysosomal granules in T-PLL cells which results in a higher content of acid hydrolases. The intriguing relationship of B-PLL with B-CLL is discussed in the light of new data with immunological markers.

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