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Prolymphocytic leukaemia.

D Catovsky

    Nouvelle Revue Francaise D'Hematologie
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    This review distinguishes between B-cell and T-cell prolymphocytic leukemia (PLL). T-cell PLL is more aggressive, with shorter survival and distinct cellular features compared to B-cell PLL.

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    Area of Science:

    • Hematology
    • Oncology
    • Immunology

    Background:

    • Prolymphocytic leukemia (PLL) is a rare lymphoid malignancy.
    • Distinguishing between B-cell and T-cell subtypes is crucial for prognosis and treatment.

    Purpose of the Study:

    • To review the main features of prolymphocytic leukaemia.
    • To differentiate between B-cell (B-PLL) and T-cell (T-PLL) forms based on immunological markers and clinical data.

    Main Methods:

    • Analysis of 80 cases of prolymphocytic leukaemia studied since 1974.
    • Characterization of cell surface phenotypes (B-cell vs. T-cell markers).
    • Ultrastructural analysis of leukaemic cells.

    Main Results:

    • 81% of cases exhibited a B-cell phenotype (B-PLL), while the remainder showed T-cell markers (T-PLL).

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  • T-PLL demonstrated a more aggressive clinical course with a median survival of 7 months, versus 24 months for B-PLL.
  • T-PLL cells showed larger lysosomal granules and higher acid hydrolase content.

    • Conclusions:

    • B-cell and T-cell prolymphocytic leukaemia present with distinct laboratory and clinical findings.
    • T-cell PLL is associated with a significantly poorer prognosis.
    • Further investigation into the relationship between B-PLL and B-cell chronic lymphocytic leukemia (B-CLL) is warranted.