Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pancreatic autotransplantation.

N T McPhedran, R A Attisha, S A Ross

    Transplantation Proceedings
    |December 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Performance and environmental impact of egg production in response to dietary supplementation of mannan oligosaccharide in laying hens: a meta-analysis.

    Poultry science·2022
    Same author

    Effect of neck flexor muscle activation on impact velocity of the head during backward falls in young adults.

    Clinical biomechanics (Bristol, Avon)·2017
    Same author

    Relative emissions intensity of dairy production systems: employing different functional units in life-cycle assessment.

    Animal : an international journal of animal bioscience·2017
    Same author

    Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies.

    Chemical communications (Cambridge, England)·2016
    Same author

    Initial combination of linagliptin and metformin compared with linagliptin monotherapy in patients with newly diagnosed type 2 diabetes and marked hyperglycaemia: a randomized, double-blind, active-controlled, parallel group, multinational clinical trial.

    Diabetes, obesity & metabolism·2014
    Same author

    Incretin-based therapy in combination with basal insulin: a promising tactic for the treatment of type 2 diabetes.

    Diabetes & metabolism·2012

    Successful segmental pancreatic autotransplantation requires enhanced splenic artery blood flow via jump graft or fistula, plus anticoagulation. Graft perfusion is unnecessary, and up to 3 hours of ischemia is tolerated.

    Area of Science:

    • Surgical techniques
    • Transplantation immunology
    • Gastroenterology

    Background:

    • Segmental pancreatic autotransplantation is a complex procedure.
    • Optimizing graft survival and function is crucial for successful outcomes.
    • Technical variations can significantly impact graft viability.

    Purpose of the Study:

    • To identify critical technical factors for successful segmental pancreatic autotransplantation.
    • To evaluate the impact of different arterial reconstruction methods on graft survival.
    • To determine optimal post-transplantation management strategies.

    Main Methods:

    • Comparison of jump graft versus distal fistula for splenic artery anastomosis.
    • Assessment of graft perfusion necessity and tolerance to ischemia.

    Related Experiment Videos

  • Evaluation of graft location and preservation of adjacent arteries.
  • Monitoring of graft function using blood glucose levels and other biomarkers.

    • Main Results:

    • Enhanced splenic artery blood flow, particularly via the jump graft method, significantly improved success rates.
    • Anticoagulation was essential for successful outcomes.
    • Perfusion of the isolated graft was not necessary and potentially detrimental.
    • Ischemia up to 3 hours was well tolerated.
    • Preservation of the left gastric artery reduced mortality.
    • Blood glucose monitoring was the most reliable indicator of graft function and loss.

    Conclusions:

    • The jump graft technique for splenic artery anastomosis, combined with anticoagulation, is the most successful method for segmental pancreatic autotransplantation.
    • Careful surgical technique, including preservation of the left gastric artery, and appropriate post-operative monitoring are key to successful outcomes.
    • Routine monitoring of blood glucose is sufficient for assessing graft function and detecting graft loss.