Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cellular immunity in leprosy patients].

M S de Arruda, O S de Arruda, R N Fleury

    Medicina Cutanea Ibero-Latino-Americana
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus.

    The British journal of dermatology·2017
    Same author

    Demographic characterization of Brazilian patients enrolled in the Fabry Registry.

    Genetics and molecular research : GMR·2013
    Same author

    Integrated optic head for sensing a two-dimensional displacement of a grating scale.

    Applied optics·2010
    Same author

    Neurophysiological patterns of ulnar nerve neuropathy in leprosy reactions.

    Leprosy review·2010
    Same author

    Integrated optic wavelength demultiplexer using a coplanar grating lens.

    Applied optics·2010
    Same author

    Aberration characterizations of a focusing grating coupler in an integrated-optic disk pickup device.

    Applied optics·2010
    Same journal

    [Acquired bullous epidermolysis and multiple myeloma].

    Medicina cutanea ibero-latino-americana·1990
    Same journal

    [Eosinophilic ulcer of the tongue. Pathogenic role of eosinophils].

    Medicina cutanea ibero-latino-americana·1990
    Same journal

    [Facial granuloma caused by cactus bristles].

    Medicina cutanea ibero-latino-americana·1990
    Same journal

    [Epithelioid sarcoma. Immunohistochemical study. Therapy with recombinant alfa interferon].

    Medicina cutanea ibero-latino-americana·1990
    Same journal

    [Dyshidrosiform pemphigoid].

    Medicina cutanea ibero-latino-americana·1990
    Same journal

    [Metastatic alopecia].

    Medicina cutanea ibero-latino-americana·1990
    See all related articles

    Cellular immunity in arrested lepromatous leprosy patients was assessed using various tests. Results indicate specific immune responses, suggesting a distinct sub-population within lepromatous leprosy.

    Area of Science:

    • Immunology
    • Dermatology
    • Infectious Diseases

    Background:

    • Lepromatous leprosy is a form of leprosy characterized by significant immune dysregulation.
    • Evaluating cellular immunological competence is crucial for understanding disease progression and treatment efficacy.

    Purpose of the Study:

    • To assess the cellular immunological competence of clinically arrested lepromatous leprosy patients.
    • To investigate potential cross-reactivity between different immunological tests.
    • To determine the influence of sulfone therapy on immunocellular results.

    Main Methods:

    • Forty-eight clinically arrested lepromatous leprosy patients underwent testing for cellular immunity.
    • Tests included purified protein derivative (PPD), Trichophytin, 2,4-dinitrochlorobenzene (DNCB), T lymphocyte percentage, and lepromin reactions (early and late).

    Related Experiment Videos

  • Histopathological examination of Mitsuda reactions was performed.

    • Main Results:

    • Lepromatous patients showed positive PPD test results more frequently than controls.
    • All patients were positive for DNCB and negative for the Fernandez reaction.
    • Late lepromin reactions were negative, but histopathology revealed varying degrees of reactivity, including granulomatous inflammation.
    • No cross-reactivity was observed between PPD and lepromin tests.

    Conclusions:

    • Sulfone therapy did not interfere with the immunocellular results of the employed tests.
    • Lepromatous patients responded similarly to the general population in unspecific sensitivity tests.
    • Histopathological findings in Mitsuda reactions suggest a sub-population of borderline patients within the lepromatous group.