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Mandibular morphogenesis and craniofacial malformations.

B K Hall

    Journal of Craniofacial Genetics and Developmental Biology
    |January 1, 1982
    PubMed
    Summary
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    Morphogenesis, the change in shape during development, is an intrinsic property of neural crest and mesenchymal cells. Defects in mandibular development, from neural crest cell migration to tissue interactions, cause craniofacial malformations.

    Area of Science:

    • Developmental biology
    • Cell biology
    • Craniofacial biology

    Background:

    • Morphogenesis is defined as the development or change of shape, distinct from differentiation and growth.
    • It can be studied at various levels, with a focus on cells, tissues, and organs.
    • Understanding mandibular development involves tracing the origin, migration, and differentiation of neural crest and other contributing cells.

    Purpose of the Study:

    • To define morphogenesis and its relation to development.
    • To review mandibular development, including cellular origins and pathways.
    • To explore the intrinsic control mechanisms of mandibular morphogenesis.
    • To identify the developmental basis of craniofacial malformations.

    Main Methods:

    • Review of existing literature on morphogenesis and craniofacial development.

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  • Analysis of evidence regarding the intrinsic properties of mesenchymal cells in morphogenesis.
  • Examination of studies on neural crest cell transplantation and its developmental outcomes.
  • Synthesis of data on various defects leading to craniofacial malformations.

    • Main Results:

    • Morphogenesis is an intrinsic property of mesenchymal cells, dictating skeletal element shape and number.
    • Neural crest cells exhibit intrinsic properties that guide their morphogenetic contributions, even in ectopic sites.
    • Defects in neural crest cell migration, tissue interactions, or epigenetic regulation can lead to craniofacial malformations.

    Conclusions:

    • Mandibular morphogenesis is controlled intrinsically by neural crest and mesenchymal cells.
    • Craniofacial malformations arise from disruptions at any stage of mandibular development.
    • Identifying specific cellular defects is crucial for developing corrective strategies for craniofacial malformations.