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Polymorphic transition in bacterial flagella.

R Kamiya, H Hotani, S Asakura

Symposia of the Society for Experimental Biology

|January 1, 1982

Summary

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Bacterial flagella change shape at different pH levels, transitioning between helical forms. This structural polymorphism is explained by a two-state model, revealing insights into bacterial motility and evolution.

Area of Science:

Microbiology
Biophysics
Structural Biology

Background:

The bacterial flagellum is a complex motility organelle.
Understanding flagellar structure-function relationships is key to bacterial physiology.

Purpose of the Study:

To describe the basic structure of the bacterial flagellum shaft.
To investigate flagellar polymorphism and its underlying mechanisms.

Main Methods:

Flow-birefringence to study pH-induced transitions.
Dark-field light microscopy of reconstituted flagella.
Optical diffraction studies of flagellar structure.
Co-polymerization of flagellins from mutants.

Main Results:

Related Experiment Videos

Wild-type Salmonella flagella exhibit pH-dependent helical polymorphism.

Transitions to distinct helical forms observed at specific pH values and KCl concentrations.

A two-state model accurately predicts helical structure and polymorphism.

Co-polymerization of mutant flagellins mimics natural polymorphic forms.

Conclusions:

Bacterial flagellar structure is dynamic and responsive to environmental conditions.
The two-state model provides a framework for understanding flagellar polymorphism.
Flagellar polymorphism has implications for bacterial motility and evolution.