[Congenital pachyonychia treated by oral retinoid]

One female patient 18 years old who suffers from Congenital Uaquioniquis since infancy, with serious alterations of nails, was treated with oral retinoid (Ro 10-9359-Tigason) during 20 months, with clinical improvement of her lesions. Clinical and laboratory controls were carried out periodically and they did not show any alterations. The only side-effects were itching, discrete hair loss headache, chelitis, all which were moderate in degree and transient.