Prophylaxis of infection in keratoplasty

The necessity for special operating rooms used exclusively for intraocular surgery, careful preparation of the patient and prevention of infection with preoperative antibiotics is emphasized. Also, the graft must be obtained and stored in aseptic and atraumatic conditions. If, in spite of these precautions postoperative endophthalmitis does occur, the graft must be replaced by a fresh donor cornea and the purulent material eliminated by irrigation, as long as the infection is still limited to the anterior segment of the eye.