Experimental glomerulonephritis

Our current understanding of glomerulonephritis has been established on the basis of experimental investigations. As shown in this short review, our knowledge is quite extensive, but still not enough to account for, in detail, the pathogenesis of diverse inflammatory processes occurring in the renal glomerulus. In this context, further correlated morphologic and immunopathologic studies need to be carried out. Fortunately, recent progress has been remarkable in revealing many possible chemical substances responsible for the mediation of various inflammations which may certainly encourage our experimental studies. Similarly, numerous new findings accumulated by basic immunology may be ready for application to the research about immunologic diseases, including many categories of glomerulonephritis. A modern immunologic aspect may also direct attention towards the immunologic background modulating inflammatory processes. It is expected that these possible future studies, in concert, will contribute to a comprehensive understanding of human glomerular diseases.