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Reflex hypoglycemia initiated by insulin.

R Alvarez-Buylla, S A Bencosme

    Acta Physiologica Latino Americana
    |January 1, 1981
    PubMed
    Summary

    Small amounts of insulin trigger a hypoglycemic reflex in rabbits, affecting arterial insulin response (IRI) and glucose levels. This reflex appears mediated by the vagus nerve, influencing glucose uptake in brain and muscle tissues.

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    Area of Science:

    • Endocrinology
    • Neuroscience
    • Physiology

    Background:

    • Insulin's role in glucose regulation is complex.
    • The vagus nerve plays a significant role in metabolic control.
    • Local insulin secretion and its systemic effects require further investigation.

    Purpose of the Study:

    • To investigate the effects of localized insulin injection in the coeliac trunk on glucose metabolism and insulin response in rabbits.
    • To determine the role of the abdominal vagi in mediating insulin-induced hypoglycemia.
    • To explore the potential for a localized hypoglycemic reflex triggered by insulin.

    Main Methods:

    • Insulin was injected into the coeliac trunk of anesthetized rabbits.
    • Experiments were conducted in both intact and abdominal-vagotomized rabbits.
    • Electrical stimulation of the abdominal vagi was performed.

    Main Results:

    • Insulin injection in the coeliac trunk caused a rapid rise in arterial insulin response (IRI) and a drop in glucose levels, increasing the arterial-venous glucose difference.
    • These effects were abolished in vagotomized rabbits, despite similar IRI increases.
    • Vagal stimulation led to increased arterial glucose and decreased venous glucose, suggesting a reflex mechanism.

    Conclusions:

    • Localized insulin delivery to the coeliac trunk can trigger a hypoglycemic reflex.
    • The abdominal vagus nerve is crucial for mediating this insulin-induced hypoglycemic reflex.
    • This reflex may involve increased glucose uptake by brain and leg muscle mass.

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